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KMID : 0358319920330020294
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Korean Journal of Urology
1992 Volume.33 No. 2 p.294 ~ p.297
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Effect of Bethanechol Chloride on Rabbit Bladder Neck Contractility: In-Vitro Study
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Abstract
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Bethanechol promotes bladder emptying by acting on postganglionic parasympathetic effector cells within detrusor muscle to elicit a contraction and is widely used to enhance bladder emptying for incomplete lower motor neuron lesion, idiopathic
hypotonic
bladder and postoperative urinary retention. However its effects on bladder outlet is inconclusive. Therefore, in vitro study for the effects of bethanechol on the muscle strip from the rabbit bladder neck were undertaken. Ten male white rabbit
bladders
were divided into body, base and neck and contractile responses of three strips were done. Bethanechol chloride produces most potent contractile response on the bladder body and comparatively less on the bladder base and bladder neck in a
dose-dependant
manner.
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KEYWORD
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